ABSTRACT
One of the major problems when evaluating dyspeptic patients at public hospitals is the large interval between the consultation and the endoscopy, leading to the prescription of antisecretory drugs, what can be responsible for false results on examinations. AIM: To evaluate changes in ultrarapid urease test and histopathological examination for Helicobacter pylori by antisecretory drugs. METHODS: In a prospective double-blind study, 50 patients with dyspeptic complaints and endoscopic diagnosis of peptic ulcer, erosive gastritis, esophagitis or duodenitis, with a positive urease test, were randomized to a 7-day course of treatment with either omeprazole 20 mg or ranitidine 300 mg a day. Before and after treatment, two biopsy specimens each were obtained from the antrum and corpus and an ultrarapid urease test and a histopathological examination for Helicobacter pylori were performed. RESULTS: There were no significant changes in the results of ultrarapid urease test and histopathological examination for Helicobacter pylori after treatment with ranitidine. With omeprazole, we observed a decrease in positive results in ultrarapid urease test and histopathological examination for Helicobacter pylori in the antrum, but not in the corpus. CONCLUSION: Omeprazole, used for 7 days, can lead to negative results in ultrarapid urease test and histopathological examination for Helicobacter pylori in the antrum, and should not be employed in patients before the endoscopy is performed.
Subject(s)
Humans , Adult , Middle Aged , Male , Female , Anti-Ulcer Agents/adverse effects , Gastrointestinal Diseases/drug therapy , Helicobacter Infections/pathology , Helicobacter pylori/isolation & purification , Histamine H2 Antagonists/adverse effects , Urease/analysis , Double-Blind Method , Gastric Mucosa/drug effects , Gastric Mucosa/microbiology , Gastrointestinal Diseases/microbiology , Helicobacter Infections/microbiology , Helicobacter pylori/drug effects , Omeprazole/adverse effects , Prospective Studies , Ranitidine/adverse effectsABSTRACT
Os autores revisam, brevemente, a ocorrência e o diagnóstico da infecçäo na necrose pancreática, bem como o papel dos antibióticos na profilaxia de infecçöes na pancreatite aguda.